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pentobarbital will decrease the level or effect of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Double brexpiprazole dose over one-two months if administered with a strong CYP3A4 inducer.pentobarbital will decrease the extent or effect of ibuprofen by impacting hepatic enzyme CYP2C9/10 metab